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Biological Chemistry II >> Content Detail



Lecture Notes



Lecture Notes

The table below includes an example set of notes taken by a student in the course for each lecture session (L#).

SES #TOPICS
Module 1: Size and Components of Cells and Implications with respect to Regulation
L1Introduction: cell constituents, prokaryotes vs. eukaryotes (PDF)
L2Introduction (cont'd) (PDF)
Module 2: Fatty Acid Synthases (FAS), Polyketide Synthases (PKS), and Non-ribosomal Polypeptide Synthases (NRPS)
L3Fatty Acid Synthase: polymerization, biosynthesis, players, chemistry, structure, chemistry as a paradigm for PKS and NRPS, medical interlude (PDF)
L4Experimental methods for elucidating FAS structure (PDF)
L5Chemistry of FAS as paradigm for other molecular machines (PDF)
L6Secondary metabolism: PKS, NRPS (PDF)
L7Chemistry of PKS and NRPS: post-translational modification, initiation, elongation, decoration, termination, fidelity (PDF)
L8Chemistry of PKS and NRPS (cont'd) (PDF)
L9Chemistry of PKS and NRPS (cont'd with specific examples) (PDF)
L10Biosynthesis of yersiniabactin and cholesterol (PDF)
L11Cholesterol biosynthesis (PDF)
L12Cholesterol regulation and homeostasis (PDF)
L13Sensing insoluble molecules (PDF)
L14Module 2: Regulation of the transcription level by insoluble metabolites and Module 3: Translation (PDF)
Module 3: Translation: Loading, Initiation, Elongation, and Termination - A Machine in Action; Introduction to G-proteins: Switches or Motors
L15Translation (cont'd) (PDF)
L16Elongation, termination, RNA polymerase (PDF)
L17Chemical methods for studying translation and the ribosome (PDF)
L18Chemical methods for studying translation and the ribosome (cont'd) (PDF)
L19Chemical methods for studying translation and the ribosome (cont'd) (PDF)
L20Isoleucine tRNA synthetase (PDF)
L21tRNA synthase editing mechanisms; G proteins (EF-Tu/EF-G) (PDF)
L22G proteins: motors (PDF)
L23G proteins: switches (PDF)
L24Peptide bond formation; new technologies using the ribosome (PDF)
L25Module 3: methods for the incorporation of unnatural amino acids and Module 4: what happens as a protein exits the ribosome? (PDF)
Module 4: Crypts and Chambers: Macromolecular Machines involved in Protein Folding and Degradation
L26Protein folding in vitro (PDF)
L27Protein folding: in vitro vs. in vivo; degradation (PDF)
L28Protein folding in vivo  (PDF)
L29Chaperone proteins (PDF)
L30GroEL/GroES (PDF)
L31Proteases (PDF)
L32Proteosome (PDF)
L33Proteosome (cont'd) (PDF)
L34Role of Ubiquitin in degradation (PDF)
L35Degradation through polyubiquitination (PDF)

 








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