| SES # | TOPICS | KEY DATES |
|---|---|---|
| 1 | Introduction to the problem | Assignment 1 out |
| 2 | Side-chain review Sulfur redox chemistry | |
| 3 | The Anfinsen experiments | Assignment 2 out |
| 4 | Globular protein structure Protein interiors | |
| 5 | Using the Protein Database (PDB) | Assignment 3 out |
| 6 | Helix-helix packing in globular proteins | |
| 7 | Beta-sheets Beta-sheet packing | |
| 8 | Experimental techniques: circular dichroism | Assignment 4 out |
| 9 | Thermal denaturation Coiled coils Refolding of Tropomyosin | |
| 10 | Fluorescence spectroscopy | Assignment 5 out |
| 11 | S-peptide helical folding | |
| 12 | Detecting partially folded intermediates | |
| 13 | Prolyl isomerization | Assignment 6 out |
| 14 | Cytochrome c refolding pathway | |
| 15 | 2-D NMR techniques | Assignment 7 out |
| 16 | Collagen structure and folding in vivo | |
| 17 | Procollagen folding in vitro | |
| 18 | Protein calorimetry: BPTI | |
| 19 | Protein misfolding and aggregation | |
| 20 | Ribosome channel Nascent chains Trigger factor | Graded problem set due |
| 21 | Scaffolding proteins in viral shell assembly | |
| 22 | Amyloid fiber formation in neuro degenerative disease | |
| 23 | Mid-term exam | |
| 24 | Chaperonin assisted folding | |
| 25 | Eukariotic chaperonins | |
| 26 | Paper topic discussion and choices | |
| 27 | Membrane protein (rhodopsin) folding and assembly | |
| 28 | Prion diseases | |
| 29 | Etiology of some human protein deposition diseases | |
| 30-37 | Student presentations | |
| 38 | Final papers due |